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2nd edition launch

Principles of Clinical Cannabinology

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Pre-order your copy now and save 30%!

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Digital and paperback editions will be available in Autumn 2024.

What's new in this 2nd edition? 

Scientific findings

The latest scientific discoveries on the pharmacology of phytocannabinoids and other compounds in the cannabis plant have been incorporated, along with the introduction of the innovative concept of Neuro-Gastro-Cannabinology.

Insights on new countries

Chapter four has been expanded to include the growing acceptance of medical cannabis in additional countries such as France, Spain, and Greece.

Clinical applications

Newly recognized conditions responsive to medical cannabis treatment have been included, along with fresh clinical cases and treatment examples from healthcare professionals prescribing cannabis worldwide.

Pre-order your copy now and save 30%!

Discount code: PREORDER30

Digital and paperback editions will be available in Autumn 2024.


Chapter 1: The Endocannabinoid System
  • 1.1 Endocannabinoid System
  • 1.2 Endocannabinoid System and Pain
  • 1.3 The Endocannabinoid System in the Gastrointestinal Tract
  • 1.4 How the Endocannabinoid System regulates sexual activity and birth
  • 1.5 The Endocannabinoid System and the sleep-wake cycle: The role in insomnia
  • 1.6 Insight: Palmitoylethanolamide (PEA)
  • 1.7 Insight: Homeostasis, resilience and the Endocannabinoid System, a holistic approach to mitigate Covid-19 stress
  • 1.8 Insight: The role of the Endocannabinoid System in stress anxiety
Chapter 2: Therapeutic Aspects of the Cannabis Sativa L. Plant
  • 2.1 Medical Cannabis: General aspects
  • 2.2 How to use Medical Cannabis
  • 2.3 Pharmacology of tetrahydrocannabinol (THC). Can side effects be separated from therapeutic effects?
  • 2.4 Pharmacology of cannabidiol (CBD)
  • 2.5 Pharmacology of minor phytocannabinoids
  • 2.6 Insight: Cannabis, four new phytocannabinoids identified
  • 2.7 Insight: Heterologous production of cannabinoids
  • 2.8 Insight: Guide to delta-8-THC and delta-10-THC
  • 2.9 Insight: Not just cannabinoids, the link between tryptophan and cannabis
Chapter 3: Pathologies that Benefit from Therapeutic Cannabis
  • 3.1 Pathologies where Cannabis has shown therapeutic efficacy
  • 3.2 Cannabis in neurological and neurodegenerative diseases
  •             3.2.1 Parkinson’s disease and Cannabis
  •             3.2.2 Cannabis for Alzheimer’s and beyond: elderly, the clinical protocol
  • 3.2.3 Childhood epilepsy, cannabis-based therapies, and CBD side effects
  • 3.2.4 Cannabis and Multiple Sclerosis: analysis of major clinical trials
  • 3.3 Cannabis in disorders of the musculoskeletal system
  •             3.3.1 Medical Cannabis in orthopedics: cannabinoids and the musculoskeletal system
  •              3.3.2 Muscular Dystrophy and Cannabis
  •             3.3.3 Topical applications of CBD: transdermal patches with muscle relaxant effects
  •             3.3.4 CBD in the treatment of low back pain
  •             3.3.5 Insight: What are the effects of CBD? Can it be used in sports?
  • 3.4 Cannabis in cardiovascular disorders
  •             3.4.1 Cannabis and cardiovascular disease
  •             3.4.2 Cannabis and hypertension in elderly patients: a clinical study
  •             3.4.3 Cannabidiol for infants: ischemia and CBD
  • 3.5 Cannabis in metabolic disorders
  •             3.5.1 Cannabis and diabetes: pros and cons
  • 3.5.2 Cannabis and obesity: role of THCA
  • 3.6 Skin diseases and the Endocannabinoid System
  • 3.7 Cannabis and chronic inflammatory bowel disease (IBD)
  • 3.8 CBD in neuropsychiatry: the effects of Cannabidiol in the brain
  •             3.8.1 Post-Traumatic Stress and how Cannabis can help
  • 3.9 What is autism and how to treat it with CBD: two case studies from Brazil
  •             3.9.1 Hands-on experience: CBD in attention deficit hyperactivity disorder (ADHD)          
  •             3.9.2 Insights from MDs: Cannabinoids for Autism and ADHD
  • 3.10 Cannabis and glaucoma
  • 3.11 Burning Mouth and Cannabis
  • 3.12 Medical Cannabis and Palliative Care
  • 3.12.1 Cannabis and glioblastoma: tolerability and efficacy of Sativex®
  • 3.13 Cannabis in the treatment of migraine.
  • 3.14 The effects of Cannabis and phytocannabinoids on sleep and insomnia
  • 3.15 Drug interaction with cannabinoids
  • 3.16 Insight: Cannabis and cannabigerol (CBG) against antibiotic resistance
  • 3.17 Insight: Cannabis consumption, data from an American study
  • 3.18 Insight: CBD and Covid-19: the treatment of symptoms
  • 3.19 Insight: THC in the treatment of ARDS: possible role in COVID-19 infection?
Chapter 4: Medical Cannabis Regulation in Europe
  • 4.1 Premise
  • 4.2 Belgium
  • 4.3 Czech Republic
  • 4.4 Denmark
  • 4.5 France
  • 4.6 Germany
  • 4.7 Greece
  • 4.8 Italy
  • 4.9 Ireland
  • 4.10 Malta
  • 4.11 Portugal
  • 4.12 Spain
  • 4.13 Sweden
  • 4.14 Switzerland
  • 4.15 UK
  • 4.16 Poland
Chapter 5: Conclusion
  • Conclusions & Closing Remarks

Foreword by Daniele Piomelli, PhD

Daniele Piomelli - Cannabiscientia

Daniele Piomelli, PhD
University of California

[...] In Principles of Clinical Cannabinology, Cannabiscientia provides a comprehensive and easy-to-read guide to the clinical use of cannabis, covering its history, pharmacology, therapeutic applications, and potential benefits and drawbacks. They have in mind as readers healthcare professionals, students, researchers, and patients who seek to understand the science behind cannabis based medicine and its possible roles in treating a wide range of medical conditions. The book is organized in several chapters, each followed by a useful list of references to primary articles and reviews. Throughout the book, the authors draw on the latest scientific research and extensively on anecdotal evidence to present a view of cannabis that strives to be both balanced and objective. There is much still to learn about this complex plant, but this clear and well-written book will serve as a valuable resource for those seeking to understand it better. [...]  Read the full foreword »

30+ Pathologies covered

Neurological diseases - Cannabiscientia


Parkinson’s disease 
Alzheimer’s disease
Childhood epilepsy
Multiple Sclerosis

Musculoskeletal diseases - Cannabiscientia


Muscular Dystrophy
Muscle relaxant effects
Low back pain
Cardiovascular disorders - Cannabiscientia


Cardiovascular disease
Hypertension in elderly patients
Ischemia in infants
Metabolic disorders - Cannabiscientia


Other pathologies - Cannabiscientia


Burning mouth
Skin diseases
Sleep & insomnia
Clinical insights - Cannabiscientia


Drug interaction
Antibiotic resistance

Pre-order your copy now and save 30%!

Discount code: PREORDER30

Digital and paperback editions will be available in Autumn 2024.

With contribution from experienced clinicians and scientists

Product and Legislative Insights on 15 EU Countries

Insights on regulations, insurance reimbursement protocols and available products


In collaboration with


Principles of Clinical Cannabinology - 2nd edition

Carefully curated clinical guidelines and case studies of experienced physicians from across the world.

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  • Ebook and paperback version available
  • 800+ scientific references
  • 600+ pages
  • 30+ pathologies 
  • 15 EU countries covered

Pre-order your copy now and save 30%!

Discount code: PREORDER30

Digital and paperback editions will be available in Autumn 2024.


 ▸ When will the 2nd edition be released?
Pre-ordering for 2nd edition of the handbook 'Principles of Clinical Cannabinology' is scheduled for June 25th, following the Cannabis Europa event in London.

Shipping Time for the Paperback Version of the Handbook:
Delivery times may vary depending on your country, typically ranging from 7 to 21 days.
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