Principles of Clinical Cannabinology

1.1. Introduction to the Endocannabinoid System

1.2. The Role of the Endocannabinoid System in Pain Management

1.3. The Endocannabinoid System in Sexual Function and Childbirth

1.4. The Endocannabinoid System and the Sleep-Wake Cycle: Implication for Insomnia

1.5. The Endocannabinoid System in the Gastrointestinal Tract

1.6. Neuro-Gastro-Cannabinology

1.7. Insight: Palmitoylethanolamide (PEA): An Overview

1.8. Insight: Homeostasis, Resilience and the Endocannabinoid System

1.9. Insight: The Endocannabinoid System and Stress-Related Anxiety

2.1. Introduction to Medical Cannabis

2.2. Delivery Methods and Pharmacokinetics of Medical Cannabis

2.3. Pharmacology of Tetrahydrocannabinol (THC)

     2.3.1. Separating THC’s Therapeutic Effects from the Side Effects

2.4. Pharmacology of Cannabidiol (CBD)

2.5. Pharmacology of Minor Phytocannabinoids

     2.5.1. Cannabigerol (CBG)
     2.5.2. Tetrahydrocannabivarin (THCV)
     2.5.3. Cannabidivarin (CBDV)

2.6. Terpenes and Flavonoids

2.7. Exploring Four New Phytocannabinoids in Cannabis

2.8. Understanding Delta-8-THC and Delta-10-THC

2.9. Insight: The Link between Tryptophan and Cannabis

3.1. Pain and Other Pathologies for which Cannabis Has Shown Therapeutic Efficacy

     3.1.1. Case Studies: Fibromyalgia
     3.1.2. Case Studies: Chronic Pain in Adult Patients
     3.1.3. Case Studies: Chronic Pain in Elderly Patients

3.2. Cannabis Treatment in Neurological and Neurodegenerative Diseases
     3.2.1. Cannabis for Parkinson’s Disease
     3.2.2. Case Study: Parkinson’s Disease
     3.2.3. Cannabis for Alzheimer’s and Dementia: A Clinical Protocol
     3.2.4. Cannabis, CBD and Epilepsy
     3.2.5. Case Study: Drug-Resistant Epilepsy in Adults
     3.2.6. Cannabis for Multiple Sclerosis
     3.2.7. Case Study: Multiple Sclerosis

3.3. Cannabis Therapy for Musculoskeletal Disorders

     3.3.1. Cannabinoids and Musculoskeletal Health
     3.3.2. Cannabis for Muscular Dystrophy
     3.3.3. CBD for Temporomandibular Pain
     3.3.4. CBD Treatment for Low Back Pain
     3.3.5. Cannabis Use in Sports Medicine

3.4. Cannabis and Cardiovascular Disorders

     3.4.1. Cannabis in Cardiovascular Diseases
     3.4.2. Cannabis and Hypertension in Elderly Patients
     3.4.3. Cannabidiol for Infant Ischemia

3.5. Cannabis Therapy for Metabolic Disorders

     3.5.1. Medical Cannabis in Diabetes Management
     3.5.2. Cannabis and Obesity: The Role of THCA

3.6. Dermatological Diseases and the Endocannabinoid System

     3.6.1. Case Studies: Cannabinoids in Dermatology

3.7. Cannabis Treatment for Inflammatory Bowel Disease (IBD)

     3.7.1. Case Study: Crohn’s Disease

3.8. Neuropsychiatric Applications of CBD

     3.8.1. Cannabis and CBD for Post-Traumatic Stress Disorder (PTSD)
     3.8.2. Rationale for the Use of CBD for Autism and two Case Studies from Brazil
     3.8.3. Case Studies: CBD for Autism Spectrum Disorders
     3.8.4. Hands-on Experience: CBD in Attention Deficit Hyperactivity Disorder (ADHD)
     3.8.5. Case Studies: Autism and ADHD

3.9. Cannabis for Glaucoma

3.10. Cannabis-Based Mouthwashes

3.11. Medical Cannabis in Palliative Care

     3.11.1. Efficacy and Tolerability of Sativex® in Glioblastoma Patients
     3.11.2. Case Study: Breast Cancer and Related Comorbidities
     3.11.3. Case Study: Esophageal Cancer

3.12. Cannabis in the Treatment of Migraine

     3.12.1. Case Study: Cluster Headaches

3.13. The Impact of Cannabis and Cannabinoids on Sleep and Insomnia

     3.13.1. Case Study: Chronic Insomnia

3.14. Drug Interactions with Cannabinoids

3.15. Insight: Cannabis and Cannabigerol (CBG) against Antibiotic Resistance

3.16. Insight: Cannabis Use, Data from an American Study

3.17. Insight: THC in the Treatment of Acute Respiratory Distress Syndrome (ARDS)

4.1. Foreword by Prohibition Partners

4.2. Medical Cannabis Regulation in Belgium

4.3. Medical Cannabis Regulation in the Czech Republic

4.4. Medical Cannabis Regulation in Denmark

4.5. Medical Cannabis Regulation in France

4.6. Medical Cannabis Regulation in Germany

4.7. Medical Cannabis Regulation in Greece

4.8. Medical Cannabis Regulation in Ireland

4.9. Medical Cannabis Regulation in Italy

4.10. Medical Cannabis Regulation in Malta

4.11. Medical Cannabis Regulation in the Netherlands

4.12. Medical Cannabis Regulation in Poland

4.13. Medical Cannabis Regulation in Portugal

4.14. Medical Cannabis Regulation in Spain

4.15. Medical Cannabis Regulation in Sweden

4.16. Medical Cannabis Regulation in Switzerland

4.17. Medical Cannabis Regulation in the UK

4.18. Medical Cannabis Regulation: Smaller Markets

     4.18.1. Austria
     4.18.2. Croatia
     4.18.3. Finland
     4.18.4. Lithuania
     4.18.5. Luxembourg
     4.18.6. North Macedonia
     4.18.7. Norway
     4.18.8. Slovenia

Conclusions & Closing Remarks