The Handbook

The single resource healthcare professionals need to confidently prescribe medical cannabis.

Principles of Clinical Cannabinology Handbook

This publication, co-authored by Cannabiscientia SA and Prohibition Partners, is intended to be of support to the European healthcare professional, and all those interested in understanding the medical use of cannabis in Europe, merging in one single textbook a comprehensive overview of the science, regulations, medicine and products on the market.

Topics covered include the physiology of the endocannabinoid system, the pharmacology of cannabis and its clinical relevance for a number of pathologies. The Handbook also includes case studies and practical evidence of experienced prescribers around the globe that can serve as a guiding support in the obstacles of translating theory to practical applications.

This Handbook will guide the readers through the different laws regulating medical cannabis in 11 European Countries, from Belgium to the United Kingdom, and the different products available, requirements for the prescribers and the pharmacists, route for the patients to access therapy, and the availability of reimbursed medication.

Handbook Overview

1.1 Endocannabinoid System

1.2 Endocannabinoid System and Pain

1.3 The Endocannabinoid System in the Gastrointestinal Tract

1.4 How the Endocannabinoid System regulates sexual activity and birth

1.5 The Endocannabinoid System and the sleep-wake cycle: The role in insomnia

1.6 Insight: Palmitoylethanolamide (PEA)

1.7 Insight: Homeostasis, resilience and the Endocannabinoid System, a holistic approach to mitigate Covid-19 stress

1.8 Insight: The role of the Endocannabinoid System in stress anxiety

2.1 Medical Cannabis: General aspects

2.2 How to use Medical Cannabis

2.3 Pharmacology of tetrahydrocannabinol (THC). Can side effects be separated from therapeutic effects?

2.4 Pharmacology of cannabidiol (CBD)

2.5 Pharmacology of minor phytocannabinoids

2.6 Insight: Cannabis, four new phytocannabinoids identified

2.7 Insight: Heterologous production of cannabinoids

2.8 Insight: Guide to delta-8-THC and delta-10-THC

2.9 Insight: Not just cannabinoids, the link between tryptophan and cannabis

3.1 Pathologies where Cannabis has shown therapeutic efficacy

3.2 Cannabis in neurological and neurodegenerative diseases

            3.2.1 Parkinson’s disease and Cannabis

            3.2.2 Cannabis for Alzheimer’s and beyond: elderly, the clinical protocol

3.2.3 Childhood epilepsy, cannabis-based therapies, and CBD side effects

3.2.4 Cannabis and Multiple Sclerosis: analysis of major clinical trials

3.3 Cannabis in disorders of the musculoskeletal system

            3.3.1 Medical Cannabis in orthopedics: cannabinoids and the musculoskeletal system

             3.3.2 Muscular Dystrophy and Cannabis

            3.3.3 Topical applications of CBD: transdermal patches with muscle relaxant effects

            3.3.4 CBD in the treatment of low back pain

            3.3.5 Insight: What are the effects of CBD? Can it be used in sports?

3.4 Cannabis in cardiovascular disorders

            3.4.1 Cannabis and cardiovascular disease

            3.4.2 Cannabis and hypertension in elderly patients: a clinical study

            3.4.3 Cannabidiol for infants: ischemia and CBD

3.5 Cannabis in metabolic disorders

            3.5.1 Cannabis and diabetes: pros and cons

3.5.2 Cannabis and obesity: role of THCA

3.6 Skin diseases and the Endocannabinoid System

3.7 Cannabis and chronic inflammatory bowel disease (IBD)

3.8 CBD in neuropsychiatry: the effects of Cannabidiol in the brain

            3.8.1 Post-Traumatic Stress and how Cannabis can help

3.9 What is autism and how to treat it with CBD: two case studies from Brazil

            3.9.1 Hands-on experience: CBD in attention deficit hyperactivity disorder (ADHD)          

            3.9.2 Insights from MDs: Cannabinoids for Autism and ADHD

3.10 Cannabis and glaucoma

3.11 Burning Mouth and Cannabis

3.12 Medical Cannabis and Palliative Care

3.12.1 Cannabis and glioblastoma: tolerability and efficacy of Sativex®

3.13 Cannabis in the treatment of migraine.

3.14 The effects of Cannabis and phytocannabinoids on sleep and insomnia

3.15 Drug interaction with cannabinoids

3.16 Insight: Cannabis and cannabigerol (CBG) against antibiotic resistance

3.17 Insight: Cannabis consumption, data from an American study

3.18 Insight: CBD and Covid-19: the treatment of symptoms

3.19 Insight: THC in the treatment of ARDS: possible role in COVID-19 infection?

4.1 Premise

4.2 Belgium

4.3 Czech Republic

4.4 Denmark

4.6 Germany

4.6 Italy

4.7 Ireland

4.8 Malta

4.9 Portugal

4.10 Sweden

4.11 Switzerland

4.12 UK

4.13 Poland

Conclusions & Closing Remarks

A Powerful Resource

The Principles of Clinical Cannabinology can act as a powerful resource for your team including the foundation for internal staff trainings, the tool help interested physicians begin prescribing medical cannabis with confidence and the source for content for marketing.

Cannabiscientia is here to help you get the most of this powerful resource.

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Principles of Clinical Cannabinology:
A Comprehensive Guide to Medical Cannabis in Europe

Authored by Experts

Co-authored by Cannabiscientia SA and Prohibition Partners, this publication is intended to be of support to the European healthcare professional interested in medical cannabis.

Including Clinical Guidelines

A key component of our Handbook are the carefully curated clinical guidelines and case studies of experienced physicians from across Europe.

Our Handbook in Numbers

Patient Participants Cited
Scientific Literature References
Pages in the Handbook
Enrolled Students
Certified Teachers
Pathologies Covered
MD and Scientific Contributors

Complete Overview

Our Handbook covers the cannabis plant, the endocannabinoid system and the effective use of cannabinoid medicines in the treatment of various pathologies.


Each edition of our Handbook includes insights and guidelines based on the relevant jurisdictions’ regulations, insurance reimbursement protocols and available products.


Beyond the foundational understanding of the cannabis plant and the endocannabinoid system, our Handbook also provides a curated collection of clinical guidelines.

Through our educational support we hope to lead the expedited development of new and existing medical cannabis markets – comprehensive training of physicians and pharmacists with clinical guidelines to ensure everyone can begin working medical cannabis with absolute confidence.

Education. Our Specialty. Your Opportunity.


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