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Principles of Clinical Cannabinology

Second edition

A Comprehensive Guide to Medical Cannabis in Europe

Foreword by Daniele Piomelli, PhD

Daniele Piomelli - Cannabiscientia

Daniele Piomelli, PhD
University of California

[...] In Principles of Clinical Cannabinology, Cannabiscientia provides a comprehensive and easy-to-read guide to the clinical use of cannabis, covering its history, pharmacology, therapeutic applications, and potential benefits and drawbacks. They have in mind as readers healthcare professionals, students, researchers, and patients who seek to understand the science behind cannabis based medicine and its possible roles in treating a wide range of medical conditions. The book is organized in several chapters, each followed by a useful list of references to primary articles and reviews. Throughout the book, the authors draw on the latest scientific research and extensively on anecdotal evidence to present a view of cannabis that strives to be both balanced and objective. There is much still to learn about this complex plant, but this clear and well-written book will serve as a valuable resource for those seeking to understand it better. [...]  Read the full foreword »

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What's new in this 2nd edition?

Scientific findings

The latest scientific discoveries on the pharmacology of phytocannabinoids and other compounds in the cannabis plant have been incorporated, along with the introduction of the innovative concept of Neuro-Gastro-Cannabinology.

Insights on new Countries

Chapter four has been expanded to include the growing acceptance of Medical Cannabis in additional Countries such as France, Slovenia, Spain, and Greece.

Clinical applications

Newly recognised conditions responsive to medical cannabis treatment have been included, along with fresh clinical cases and treatment examples from healthcare professionals prescribing cannabis worldwide.

Products supply

This edition includes an updated overview of currently available medical cannabis products across Europe, with detailed insights into their compositions, titrations, formats (oils, inflorescences, extracts), and pricing. Clinicians will find practical tools to align therapeutic needs with product characteristics, and to navigate availability, formulation selection, and pharmacy sourcing with greater confidence.

Index

Chapter 1: Physiology of the Endocannabinoid System
  • 1.1.    Introduction to the Endocannabinoid System
  • 1.2.    The Role of the Endocannabinoid System in Pain Management
  • 1.3.    The Endocannabinoid System in Sexual Function and Childbirth
  • 1.4.    The Endocannabinoid System and the Sleep-Wake Cycle: Implication for Insomnia
  • 1.5.    The Endocannabinoid System in the Gastrointestinal Tract
  • 1.6.    Neuro-Gastro-Cannabinology
  • 1.7.    Insight: Palmitoylethanolamide (PEA): An Overview
  • 1.8.    Insight: Homeostasis, Resilience and the Endocannabinoid System
  • 1.9.    Insight: The Endocannabinoid System and Stress-Related Anxiety 
Chapter 2: Pharmacology of Cannabis and Cannabinoids
  • 2.1.    Introduction to Medical Cannabis
  • 2.2.    Delivery Methods and Pharmacokinetics of Medical Cannabis
  • 2.3.    Pharmacology of Tetrahydrocannabinol (THC)
    • 2.3.1. Separating THC’s Therapeutic Effects from the Side Effects
  • 2.4.    Pharmacology of Cannabidiol (CBD)
  • 2.5.    Pharmacology of Minor Phytocannabinoids
    • 2.5.1.    Cannabigerol (CBG)
    • 2.5.2.    Tetrahydrocannabivarin (THCV)
    • 2.5.3.    Cannabidivarin (CBDV) 
  • 2.6.    Terpenes and Flavonoids
  • 2.7.    Exploring Four New Phytocannabinoids in Cannabis
  • 2.8.    Understanding Delta-8-THC and Delta-10-THC
  • 2.9.    Insight: The Link between Tryptophan and Cannabis
Chapter 3: Medical Cannabis in Clinical Practice
  • 3.1.    Pain and Other Pathologies for which Cannabis
    Has Shown Therapeutic Efficacy
    • 3.1.1.    Case Studies: Fibromyalgia
    • 3.1.2.    Case Studies: Chronic Pain in Adult Patients
    • 3.1.3.    Case Studies: Chronic Pain in Elderly Patients
  • 3.2.    Cannabis Treatment in Neurological and Neurodegenerative Diseases
    • 3.2.1.    Cannabis for Parkinson’s Disease
    • 3.2.2.    Case Study: Parkinson’s Disease
    • 3.2.3.    Cannabis for Alzheimer’s and Dementia: A Clinical Protocol   
    • 3.2.4.    Cannabis, CBD and Epilepsy 
    • 3.2.5.    Case Study: Drug-Resistant Epilepsy in Adults
    • 3.2.6.    Cannabis for Multiple Sclerosis
    • 3.2.7.    Case Study: Multiple Sclerosis
  • 3.3.    Cannabis Therapy for Musculoskeletal Disorders
    • 3.3.1.    Cannabinoids and Musculoskeletal Health
    • 3.3.2.    Cannabis for Muscular Dystrophy
    • 3.3.3.    CBD for Temporomandibular Pain
    • 3.3.4.    CBD Treatment for Low Back Pain
    • 3.3.5.    Cannabis Use in Sports Medicine
  • 3.4.    Cannabis and Cardiovascular Disorders
    • 3.4.1.    Cannabis in Cardiovascular Diseases
    • 3.4.2.    Cannabis and Hypertension in Elderly Patients
    • 3.4.3.    Cannabidiol for Infant Ischemia
  • 3.5.    Cannabis Therapy for Metabolic Disorders
    • 3.5.1.    Medical Cannabis in Diabetes Management
    • 3.5.2.    Cannabis and Obesity: The Role of THCA
  • 3.6.    Dermatological Diseases and the Endocannabinoid System
    • 3.6.1.    Case Studies: Cannabinoids in Dermatology
  • 3.7.    Cannabis Treatment for Inflammatory Bowel Disease (IBD)
    • 3.7.1.    Case Study: Crohn's Disease
  • 3.8.    Neuropsychiatric Applications of CBD
    • 3.8.1.    Cannabis and CBD for Post-Traumatic Stress Disorder (PTSD)   
    • 3.8.2.    Rationale for the Use of CBD for Autism
      and two Case Studies from Brazil  
    • 3.8.3.    Case Studies: CBD for Autism Spectrum Disorders
    • 3.8.4.    Hands-on Experience:
      CBD in Attention Deficit Hyperactivity Disorder (ADHD)  
    • 3.8.5.    Case Studies: Autism and ADHD
  • 3.9.    Cannabis for Glaucoma
  • 3.10.    Cannabis-Based Mouthwashes
  • 3.11.    Medical Cannabis in Palliative Care
    • 3.11.1.    Efficacy and Tolerability of Sativex® in Glioblastoma Patients
    • 3.11.2.    Case Study: Breast Cancer and Related Comorbidities
    • 3.11.3.    Case Study: Esophageal Cancer
  • 3.12.    Cannabis in the Treatment of Migraine
    • 3.12.1.    Case Study: Cluster Headaches
  • 3.13.    The Impact of Cannabis and Cannabinoids on Sleep and Insomnia
    • 3.13.1.    Case Study: Chronic Insomnia
  • 3.14.    Drug Interactions with Cannabinoids
  • 3.15.    Insight: Cannabis and Cannabigerol (CBG)
    against Antibiotic Resistance
  • 3.16.    Insight: Cannabis Use, Data from an American Study
  • 3.17.    Insight: THC in the Treatment
    of Acute Respiratory Distress Syndrome (ARDS)
Chapter 4: Medical Cannabis Regulations, Access and Products in Europe
  • 4.1.    Foreword by Prohibition Partners
  • 4.2.    Medical Cannabis Regulation in Belgium
  • 4.3.    Medical Cannabis Regulation in the Czech Republic
  • 4.4.    Medical Cannabis Regulation in Denmark
  • 4.5.    Medical Cannabis Regulation in France
  • 4.6.    Medical Cannabis Regulation in Germany
  • 4.7.    Medical Cannabis Regulation in Greece
  • 4.8.    Medical Cannabis Regulation in Ireland
    4.9.    Medical Cannabis Regulation in Italy
  • 4.10.    Medical Cannabis Regulation in Malta
  • 4.11.    Medical Cannabis Regulation in the Netherlands
  • 4.12.    Medical Cannabis Regulation in Poland
  • 4.13.    Medical Cannabis Regulation in Portugal
  • 4.14.    Medical Cannabis Regulation in Spain
  • 4.15.    Medical Cannabis Regulation in Sweden
  • 4.16.    Medical Cannabis Regulation in Switzerland
  • 4.17.    Medical Cannabis Regulation in the UK
  • 4.18.    Medical Cannabis Regulation: Smaller Markets
    • 4.18.1.    Austria
    • 4.18.2.    Croatia
    • 4.18.3.    Finland
    • 4.18.4.    Lithuania
    • 4.18.5.    Luxembourg
    • 4.18.6.    North Macedonia
    • 4.18.7.    Norway
    • 4.18.8.    Slovenia
Chapter 5: Conclusion
  • Conclusions & Closing Remarks

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Who is it For

If you're serious about working with cannabinoid-based medicine, this book was made for you.

From seasoned doctors to PhD candidates, it offers the clarity you need to make evidence-based decisions.

What’s Inside

  • 600+ digital pages
  • Pathology-by-pathology structure
  • Product formats, legal frameworks
  • Peer-reviewed references

FAQ

Is it printed?

No. It’s a digital edition for maximum accessibility.

Can I request a bulk or institutional copy?

Not at this time.

Team members

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    Viola Brugnatelli,
    (Pres)

  • Alberto (CFO)

  • Giuseppe (CEO)

  • Barbara (CCO)

  • Fabio (CSO)

  • Cristina (Science Communication & Consulting lead)

  • Matteo Postella, CTO

Our consulting team

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Viola

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Barbara

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Jahan

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Alex

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Fabio

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Cristina

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Camilla

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Julie

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Our scientific committee

Raquel Abaladao - Cannabiscientia

Raquel Abaladao

Professor of Pharmacology
Prof. of Pharmacology, University Rey Juan Carlos; Functional Coordinator of the Area of Pharmacology, Nutrition and Bromatology.
Madrid, Spain
 
Mikael Sodergren - Cannabiscientia

Mikael Sodergren

MBChC (Hons), DIC, PhD, FRCS
Managing Director & Academic Lead, Sapphire Medical Clinics UK.
London, UK
 
 
Livio Luongo - Cannabiscientia

Livio Luongo

Assoc. Prof. of Pharmacology
Department of Experimental Medicine, Division of Pharmacology, University of Campania.
Naples, Italy
 
Marco Ternelli - Cannabiscientia

Marco Ternelli

Galenic Pharmacist
Farmacia Ternelli.
Bibbiano, Italy
 
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Janosch Kratz

Medical Doctor
Medical Director Europe, Khiron Life Sciences; Board Member, Zerenia Clinics UK.
Berlin, Germany
 
Luigi Bellocchio - Cannabiscientia

Luigi Bellocchio

Post-doc
French Institute of Health and Medical Research, Neurocentre Magendie.
Bordeaux, France
 
Javier Fernández-Ruiz - Cannabiscientia

Javier Fernández-Ruiz

Professor
Universidad Complutense, Madrid, Department of Biochemistry and Molecular Biology, School of Medicine.
Madrid, Spain
 
Ines Reynoso Moreno - Cannabiscientia

Ines Reynoso Moreno

Post-doc
Universität Bern, Doctor in Biomedical Sciences.
Bern, Switzerland
 
Katarzyna Starowicz - Cannabiscientia

Katarzyna Starowicz

Assoc. Prof. of Pharmacology
Institute of Pharmacology Polish Academy of Sciences.
Krakow, Poland
 
Adán de Salas Quiroga - Cannabiscientia

Adán de Salas Quiroga

Post-doc
Neuroscientist & medical cannabis researcher.
Madrid, Spain
 

Authored by experienced clinicians and scientists

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Marcello Albanesi - Cannabiscientia-1
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Carlo Privitera - Cannabiscientia
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In collaboration with

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